Depression: UK Online Doctor Diagnosis & Treatment Guide
Educational information — not medical advice.
This article was prepared by the OnlineDoctor24 editorial team and reviewed for factual accuracy against UK clinical guidance (NHS and NICE). It is not written by a doctor and does not replace personal medical advice. For symptoms specific to you, book an online doctor consultation.
Key points
- Depression is more than feeling sad — it's persistent low mood lasting weeks, with loss of interest, sleep changes and low energy.
- First-line: lifestyle measures, CBT and (if moderate or worse) an SSRI antidepressant.
- PHQ-9 is the standard UK assessment tool.
- Most antidepressants take 4–6 weeks for full effect.
- An online doctor can assess, prescribe and refer to therapy.
Symptoms
- Persistent low mood for 2+ weeks
- Loss of interest or pleasure (anhedonia)
- Fatigue, reduced energy
- Sleep changes (insomnia or oversleeping)
- Appetite/weight changes
- Feelings of guilt, worthlessness, hopelessness
- Difficulty concentrating
- Thoughts of self-harm
Self-care
- Behavioural activation — small daily activities, even when motivation is low.
- Regular movement and sleep.
- Limit alcohol — it worsens depression.
- Connect with one trusted person.
Talking therapies
NHS Talking Therapies offers free CBT. Self-refer online via your local service. Private CBT and counselling provide faster access.
Antidepressants
- First line: sertraline 50 mg, citalopram 20 mg, escitalopram 10 mg.
- Alternative: mirtazapine if sleep/appetite poor; venlafaxine for severe cases.
- Continue for at least 6 months after recovery; longer if recurrent.
- Taper slowly — never stop abruptly.
Red flags — when to seek urgent help
Call 999 or go to A&E if you experience any of the following:
- Active thoughts of suicide or self-harm — call 999 or Samaritans 116 123
- Plans to end your life — go to A&E
- Severe agitation or psychotic symptoms
Frequently asked questions
Common questions UK patients ask about depression.
How an online doctor can help
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This article is for general information only and does not replace personal medical advice from a qualified doctor. Content is reviewed against UK NHS and NICE guidance by the OnlineDoctor24 editorial team and is not authored by a medical doctor. If your symptoms worsen or you are unsure, please book a consultation with a GMC-registered GP.
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